Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Cyclocytidine HCl 10212-25-6 200mg
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Cyclocytidine HCl (10212-25-6) is a small-molecule nucleoside analog designed to interfere with nucleic acid metabolism and DNA replication Cyclocytidine HCl exerts its biological activity primarily through intracellular conversion into active phosphorylated metabolites that disrupt DNA and RNA synthesis pathways In experimental studies Cyclocytidine HCl demonstrates antitumor activity particularly against leukemia cell lines with reported IC50 values ranging from low micromolar to submicromolar concentrations depending on specific cellular assays and conditions Based on these pharmacological properties Cyclocytidine HCl holds research potential in mechanistic investigations of leukemia pathology and assessment of nucleoside analog efficacy
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Apexbio Technology LLC Sotalol 3930-20-9 200mg
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Sotalol (CAS 3930-20-9) is a non-selective adrenergic beta-receptor antagonist that inhibits both 1- and 2-adrenergic signaling pathways By blocking these receptors sotalol reduces sympathetic stimulation of the myocardium leading to decreased heart rate and myocardial contractility Furthermore it exhibits class III antiarrhythmic properties by prolonging cardiac action potential duration through inhibition of potassium channels Sotalol is utilized in biomedical research for investigating mechanisms underlying arrhythmogenesis and for evaluating therapeutic strategies in models of life-threatening ventricular and supraventricular arrhythmias
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000420872 DIHYDROERGOCRISTINE 5MG
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eMolecules Ambeed / 2-Hydroxyquinoline-3-carboxylic acid / 100mg / 600839469 / A400246 / / 2003-79-4 / MFCD01110561 / 189.170 / C10H7NO3
Ambeed / 2-Hydroxyquinoline-3-carboxylic acid / 100mg / 600839469 / A400246 / / 2003-79-4 / MFCD01110561 / 189.170 / C10H7NO3
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000386119 STF-31 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000433219 ETRAVIRINE 200MG
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Medchemexpress LLC Aprepitant | 170729-80-3 | MFCD08277635 | 99.8% | 534.43 g/mol | C23H21F7N4O3 | 200 MG
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Aprepitant is a selective, high-affinity neurokinin 1 (NK1) receptor antagonist used in research to probe NK1-mediated signaling and substance P pathways. It is supplied as a white to off-white solid with high stated purity and is suitable for analytical, pharmacological, and GPCR studies.
- Selective neurokinin 1 receptor antagonist.
- High affinity with a reported Kd of ~86 pM.
- High purity suitable for analytical applications.
- White to off-white solid appearance.
- Available as powder and as DMSO solutions for convenience.
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Medchemexpress LLC 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate | 406205-74-1 | 98.6% | 453.36 g·mol⁻1 | C18H13F6NO4S | 50 MG
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BAY 59-3074 is a cannabinoid CB1/CB2 receptor partial agonist originally reported by Bayer. It has been characterized in vitro and in vivo for analgesic and antihyperalgesic effects and is used in research to probe cannabinoid receptor pharmacology.
- Selective CB1/CB2 receptor partial agonist (human CB1 Ki = 48.3 nM; human CB2 Ki = 45.5 nM).
- High purity: 98.6%.
- Chemical formula C18H13F6NO4S; molecular weight 453.36 g·mol⁻1.
- Solid, white to off-white physical form, suitable for laboratory handling.
- Documented in peer-reviewed literature and product datasheets for research use.
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Apexbio Technology LLC NVP-BHG712 940310-85-0 200mg
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NVP-BHG712 (CAS 940310-85-0) is a selective small molecule inhibitor targeting the EphB4 receptor tyrosine kinase exhibiting an ED50 of 5 nM for EphB4 and reduced activity toward VEGFR2 (ED50 4200 nM) NVP-BHG712 demonstrates potent inhibition of EphB4 phosphorylation in cellular assays and shows weaker effects on EphB2 EphA2 EphB3 and EphA3 In cell-based models NVP-BHG712 suppresses proliferation and viability of synovial sarcoma cells and increases paclitaxel sensitivity in HEK293/ABCC10 cells In vivo it inhibits VEGF-induced angiogenesis and reduces tumor growth and metastasis in murine xenograft models This compound is a valuable probe for studying EphB4-mediated signaling in cancer and angiogenesis research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000386585 MEFLOQUINE 10MM 1ML
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Apexbio Technology LLC SKL2001 909089-13-0 200mg
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SKL2001 (CAS 909089-13-0) is a small-molecule agonist that selectively activates the Wnt/ -catenin signaling pathway It functions by interfering with the interaction between Axin and -catenin thereby enhancing intracellular -catenin stability In cellular studies SKL2001 has been demonstrated to suppress cancer cell proliferation This compound is widely utilized in fundamental research investigating the molecular mechanisms of cancer and serves as a tool for drug discovery targeting the Wnt/ -catenin pathway
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Apexbio Technology LLC Cy5.5 alkyne (non-sulfonated) 50mg
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Cy5 5 alkyne non-sulfonated is a near-infrared fluorescent cyanine derivative equipped with an alkyne functional group for click chemistry applications Through copper-catalyzed azide-alkyne cycloaddition (CuAAC) it forms covalent conjugates with azide-containing biomolecules metabolites or small-molecule ligands Cy5 5 alkyne non-sulfonated is primarily soluble in organic solvents aqueous solutions containing organic co-solvent such as DMSO may be used during conjugation Based on these chemical properties Cy5 5 alkyne non-sulfonated holds research potential in labeling nucleic acids peptides proteins lipids and other biomolecules for biomedical imaging tissue distribution evaluation and related pharmaceutical research applications
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000447110 DBCO-AMINE GMP 1G
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![Medchemexpress LLC 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline | 356559-20-1 | 100.0% | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234166.png-250.jpg)
Medchemexpress LLC 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline | 356559-20-1 | 100.0% | 200 MG
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SB 525334 is a selective small-molecule inhibitor of transforming growth factor-β receptor I (ALK5) used in preclinical research to block TGF-β signaling. It exhibits potent enzymatic inhibition and is supplied as a solid reagent for laboratory use.
- selective ALK5 inhibitor with IC50 = 14.3 nM
- high purity suitable for research use
- molecular formula C21H21N5 and molecular weight 343.42 g/mol
- available as a 200 MG solid pack for dosing flexibility
- stable under recommended storage conditions when stored as directed
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eMolecules 2-QUINOLINECARBOXALDEHYDE 1G
5000163075 2-QUINOLINECARBOXALDEHYDE 1G
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